Publications
Höllerhage M, Matusch A, Champy P, Lombès A, Ruberg M, Oertel WH, Höglinger GU
Natural lipophilic inhibitors of mitochondrial complex I are candidate toxins for sporadic neurodegenerative tau pathologies.
Exp Neurol, 2009 Aug 12. [Epub ahead of print]
pubmed link
Stamelou M*, Matusch A*, Elmenhorst D, Hurlemann R, Eggert KM, Zilles K, Oertel WH, Höglinger GU*,
Bauer A*
* equal contribution
Nigrostriatal upregulation of 5-HT2A receptors correlates with motor dysfunction in progressive supranuclear palsy.
Movement Disorders, 2009 Jun 15;24(8):1170-5.
pubmed link
Hermann A, Suess C, Fauser M, Kanzler S, Witt M, Fabel K, Schwarz J, Höglinger GU, Storch A
Rostro-caudal gradual loss of cellular diversity within the periventricular regions of the ventricular system,
Stem Cells, 2009 Apr;27(4):928-41.
pubmed link
Arias-Carrión O, Yamada E, Freundlieb N, Djufri M, Maurer L, Hermanns G, Ipach B, Chiu WH, Steiner C, Oertel WH, Höglinger GU.
Neurogenesis in substantia nigra of Parkinsonian brains?
J Neural Transmission Supplement, in press.
Ries V, Cheng HC, Baohan A, Kareva T, Oo TF, Rzhetskaya M, Bland RJ, During MJ, Kholodilov N, Burke RE.
Regulation of the Postnatal Development of Dopamine Neurons of the Substantia Nigra in Vivo by Akt/Protein Kinase B.
J Neurochem, 2009 Jul;110(1):23-33. Epub 2009 Apr 16.
pubmed link
Ludolph AC, Kassubek J, Landwehrmeyer BG, Mandelkow E, Mandelkow EM, Burn DJ, Caparros-Lefebvre D, Frey KA, de Yebenes JG, Gasser T, Heutink P, Höglinger G, Jamrozik Z, Jellinger KA, Kazantsev A, Kretzschmar H, Lang AE, Litvan I, Lucas JJ, McGeer PL, Melquist S, Oertel W, Otto M, Paviour D, Reum T, Saint-Raymond A, Steele JC, Tolnay M, Tumani H, van Swieten JC, Vanier MT, Vonsattel JP, Wagner S, Wszolek ZK; Reisensburg Working Group for Tauopathies With Parkinsonism.
Tauopathies with parkinsonism: clinical spectrum, neuropathologic basis, biological markers, and treatment options.
Eur J Neurol, 2009 Mar;16(3):297-309.
pubmed link
Stamelou M, Pilatus U, Reuss A, Magerkurth J, Eggert KM, Knake S, Ruberg M, Schade-Brittinger C,
Oertel WH, Höglinger GU.
In vivo evidence for cerebral depletion in high-energy phosphates in progressive supranuclear palsy
J Cereb Blood Flow Metab, 2009 Apr;29(4):861-70. Epub 2009 Feb 4.
pubmed link
Hattingen E, Lanfermann H, Menon S, Neumann-Haefelin T, Dumesnil de Rochement R,
Stamelou M, Höglinger GU, Magerkurth J, Pilatus U.
Combined (1)H and (31)P MR spectroscopic imaging: impaired energy metabolism in
severe carotid stenosis and changes upon treatment.
MAGMA. 2009 Feb;22(1):43-52. Epub 2008 Oct 15.
pubmed link
Bacher M, Depboylu C, Du Y, Noelker C, Oertel WH, Behr T, Henriksen G, Behe M,
Dodel R.
Peripheral and central biodistribution of (111)In-labeled anti-beta-amyloid
autoantibodies in a transgenic mouse model of Alzheimer's disease.
Neurosci Lett. 2009 Jan 16;449(3):240-5.
pubmed link
Ries V, Silva RM, Oo TF, Cheng HC, Rzhetskaya M, Kholodilov N, Flavell RA, Kuan CY, Rakic P, Burke RE.
JNK2 and JNK3 combined are essential for apoptosis in dopamine neurons of the substantia nigra, but are not required for axon degeneration.
J Neurochem. 2008 Dec;107(6):1578-88. Epub 2008 Nov 5.
pubmed link
Strzelczyk A, Möller JC, Stamelou M, Matusch A, Oertel WH.
[Atypical Parkinson syndromes]
Nervenarzt. 2008, Oct;79(10):1203-20; quiz 1221-2. German.
pubmed link
Eggert K, Oertel WH, Deuschl G, Gasser T, Arnold G, Baas H, Dodel R, Höglinger GU, Jost W, Reichmann H, Riederer P, Trenkwalder C, Spieker S.
Leitlinien der Deutschen Gesellschaft für Neurologie für Diagnostik und Therapie in der Neurologie: Parkinson Syndrome. 2008.
link
Deficiency of Aph1B/C-gamma-secretase disturbs Nrg1 cleavage and sensorimotor gating that can be reversed with antipsychotic treatment.
Proc Natl Acad Sci U S A. 2008 Jul 15;105(28):9775-80. Epub 2008 Jul 14.
pubmed link
Eggert K, Schrader C, Hahn M, Stamelou M, Rüssmann A, Dengler R, Oertel W, Odin P.
Continuous jejunal levodopa infusion in patients with advanced parkinson disease: practical aspects and outcome of motor and non-motor complications.
Clin Neuropharmacol. 2008 May-Jun;31(3):151-66.
pubmed link
Stamelou M, Reuss A, Pilatus U, Magerkurth J, Niklowitz P, Eggert KM, Krisp A,
Menke T, Schade-Brittinger C, Oertel WH, Höglinger GU.
Short-term effects of coenzyme Q10 in progressive supranuclear palsy: a randomized,
placebo-controlled trial.
Mov Disord. 2008 May 15;23(7):942-9.
pubmed link
Eggert K, Schrader C, Hahn M, Stamelou M, Rüssmann A, Dengler R, Oertel W, Odin P.
Continuous jejunal levodopa infusion in patients with advanced parkinson disease: practical aspects and outcome of motor and non-motor complications.
Clin Neuropharmacol. 2008;31:151-66.
pubmed link
pubmed link
Shaw CA, Höglinger GU.
Neurodegenerative Diseases: Neurotoxins as Sufficient Etiologic Agents?
Neuromolecular Med. 2008;10(1):1-9. Epub 2007 Nov 6.
pubmed link
Adult neurogenesis
and Parkinson's disease.
CNS Neurol Disord Drug Target.
2007 Oct;6(5):326-35.
pubmed link
Grgic I, Si H, Depboylu C,
Hoglinger GU, Busch C, Heyken WT, Kuhlmann U, Kohler R, Hoyer J.
Nephrol Dial Transplant. 2007 Sep 5; [Epub ahead of print]
pubmed
link
Quantitative
[(123)I]FP-CIT pinhole
SPECT imaging predicts striatal dopamine levels, but not number of
nigral neurons in differen
Neuroimage.
pubmed
link
Depboylu C, Matusch A, Tribl F, Zoriy
M, Michel PP, Riederer P, Gerlach M, Becker S, Oertel
WH,
Hoglinger GU.
Glia protects
neurons against extracellular human neuromelanin.
Neurodegener Dis. 2007;4:218-226.
pubmed
link
Becker
JS, Matusch A, Depboylu C, Dobrowolska J, Zoriy MV.
Quantitative
imaging of selenium, copper, and zinc in thin sections of biological
tissues (Slugs-Genus Arion) measured by Laser Ablation Inductively
Coupled Plasma Mass Spectrometry.
Anal Chem. 2007;79:6074-80
pubmed
link
Depboylu C, Eiden LE, Weihe E.
Increased
APOBEC3G expression is associated with extensive G-to-A hypermutation
in viral DNA in rhesus macaque brain during lentiviral infection.
J Neuropath Exp Neurol. 2007 Oct;66(10):901-12
pubmed
link
Escobar-Khondiker M, Hollerhage M, Muriel MP, Champy P, Bach A,
Depienne C, Respondek G,
Yamada ES, Lannuzel A, Yagi T, Hirsch EC, Oertel WH, Jacob R, Michel
PP, Ruberg M, Hoglinger GU.
Annonacin, a
natural mitochondrial complex I inhibitor, causes tau pathology in
cultured neurons.
J Neurosci. 2007;27:7827-37.
pubmed
link
Höglinger GU,
Breunig
JJ, Depboylu C, Rouaux C,
Michel PP, Alvarez-Fischer D, Boutillier AL, DeGregori J, Oertel
WH,
Rakic P, Hirsch EC, Hunot S.
The pRb/E2F
cell-cycle
pathway mediates cell death in Parkinson’s disease.
Proc Natl Acad Sci U S
A. 2007;104:3585–3590.
pubmed
link
Nait-Oumesmar B, Picard-Riera N,
Kerninon C, Decker L, Seilhean D, Höglinger GU, Hirsch EC, Reynolds R,
Baron-Van Evercooren A.
Activation of the Subventricular Zone in Multiple Sclerosis: evidence
for early
glial progenitors.
Proc Natl Acad Sci U S A. 2007;104: 4694–4699.
pubmed link
Lannuzel
A, Höglinger
GU,
Verhaeghe S, Gire L, Belson S, Escobar-Khondiker
M,
Poullain P, Oertel
WH,
Hirsch
EC, Dubois B, Ruberg M.
Atypical
Parkinsonism in Guadeloupe: a common risk factor for two closely
related
phenotypes?
Brain. 2007;130:816-27.
pubmed
link
Borta
A,
Höglinger GU.
Dopamine and Adult
Neurogenesis.
J. Neurochem.
2007;100:587-95.
pubmed
link
,
Francois C, Tande D, ,
Hirsch EC,
Dopaminergic
Substantia Nigra Neurons
Project Topographically Organized to the Subventricular Zone and
Stimulate
Precursor Cell Proliferation in Aged Primates.
J.
Neurosci., 2006;8:2321-2325.
Tandé D, Höglinger GU, Debeir T, Freundlieb N, Hirsch EC,
François C.
New striatal
dopamine neurons in MPTP-treated macaques result from
a phenotypic shift not neurogenesis.
Brain. 2006;129:1194–1200.
,
Lohmüller F, Du Y, Gasser T, Müller
U, Dodel RC.
a2-Macroglobulin,
lipoprotein receptor-related protein and
lipoprotein receptor-associated protein and the genetic risk for
developing
Alzheimer’s disease.
Neurosci. Lett., 2006
;400:187-90
Depboylu C, Eiden LE,
Schafer MK, Reinhart TA, Mitsuya H, Schall TJ, Weihe E.
Fractalkine
expression in the rhesus monkey brain during lentivirus infection
and its control by 6-chloro-2',3'-dideoxyguanosine.
J Neuropathol Exp Neurol. 2006;65:1170-80.
Weihe
E, Depboylu C, Schutz B, Schafer MK, Eiden LE.
Three types of
tyrosine hydroxylase-positive CNS
neurons distinguished by dopa decarboxylase and VMAT2 co-expression.
Cell
Mol Neurobiol. 2006;26:659-78.
pubmed
link
Lannuzel A,
Höglinger
GU, Champy P, Michel PP, Hirsch EC, Ruberg M.
Is Atypical
Parkinsonism in the
J Neural Transm Suppl. 2006;(70):153-7.
pubmed link
Höglinger GU, Oertel WH,
Hirsch EC,
The Rotenone Model
of Parkinsonism – The five years inspection.
J Neural Transm Suppl.
2006;(70):269-72.
pubmed link
, Lannuzel A, , Michel PP, Duyckaerts C, Féger J,
Champy P, Prigent A, Medja F, Lombes A, ,
Ruberg M, Hirsch EC.
The Mitochondrial
Complex I Inhibitor Rotenone Triggers a
Cerebral Tauopathy.
J. Neurochem.,
2005;95:930-9.
pubmed link
Champy P, Melot A, Guerineau Eng V, Gleye C, Fall D, , Ruberg M, Lannuzel A, Laprevote O, Laurens A,
Hocquemiller R.
Quantification of
acetogenins in Annona muricata linked to atypical
parkinsonism in guadeloupe.
Mov. Disord.,
2005;20:1629-33.
pubmed link
,
Michel PP, Champy P, Feger J,
Hirsch EC, Ruberg M, Lannuzel A.
Experimental
evidence for a toxic etiology of
tropical parkinsonism.
Mov Disord.,
2005;20:118-9.
pubmed link
,
Schafer MK, Schwaeble WJ, Reinhart
TA, Maeda H, Mitsuya H, Damadzic R, Rausch DM, Eiden LE, Weihe
E.
Increase of
C1q biosynthesis in brain microglia and macrophages during lentivirus
infection
in the rhesus macaque is sensitive to antiretroviral treatment with
6-chloro-2',3'-dideoxyguanosine.
Neurobiol. Dis., 2005;20:12-26.
pubmed link
Silva RM, Ries V, Oo TF, Yarygina O, Jackson-Lewis V, Ryu EJ, Lu PD, Marciniak SJ, Ron D, Przedborski S, Kholodilov N, Greene LA, Burke RE.
CHOP/GADD153 is a mediator of apoptotic death in substantia nigra dopamine neurons in an in vivo neurotoxin model of parkinsonism.
J Neurochem. 2005 Nov;95(4):974-86. Epub 2005 Aug 31.
pubmed link
Oo TF, Ries V, Cho J, Kholodilov N, Burke RE.
Anatomical basis of glial cell line-derived neurotrophic factor expression in the striatum and related basal ganglia during postnatal development of the rat.
J Comp Neurol. 2005 Mar 28;484(1):57-67.
pubmed link
,
Rizk P, Muriel MP, Duyckaerts C., ,
Caille I, Hirsch EC.
Dopamine depletion
impairs precursor cell proliferation in
Parkinson disease.
Nat. Neuroscience, 2004;7:726-35.
pubmed link
,
Rissling I, Ries V, Heinermann A, Baum E, Deuschl G, Spieker S, .
Evaluation of a
screening procedure for the early diagnosis of
Parkinsonism at the level of general practitioners.
Mov.
Disord., 2004;19:505-12.
pubmed link
Champy PF, ,
Féger J, Gleye C,
Parain K, Prigent K, Hocquemiller R, Laurens A, Lanuzel A, Hirsch EC,
Ruberg M.
Annonacin, a
lipophilic inhibitor of mitochondrial complex I,
induces nigral and striatal neurodegeneration in rats: possible
relevance for atypical parkinsonism in Guadeloupe.
J. Neurochem.,
2004;88:63-9.
pubmed link
,
Reinhart TA, Takikawa O, Imai Y,
Maeda H, Mitsuya H, Rausch D, Eiden LE, Weihe E.
Brain virus burden
and
indoleamine-2,3-dioxygenase expression during lentiviral infection of
rhesus
monkey are concomitantly lowered by 6-chloro-2',3'-dideoxyguanosine.
Eur. J. Neurosci., 2004;19:2997-3005.
pubmed link
Dodel RC, Du Y, ,
Hampel H, Frolich L,
Haag A, Hemmeter U, Paulsen S, Teipel SJ, Brettschneider S, Spottke A,
Nolker
C, Moller HJ, Wei X, Farlow M, Sommer N,
Intravenous
immunoglobulins containing antibodies against beta-amyloid for the
treatment of Alzheimer's disease.
J.
Neurol.
Neurosurg. Psychiatry., 2004;75:1472-4.
pubmed link
Anlauf M, Schafer MK, ,
Hartschuh W,
Eiden LE, Kloppel G, Weihe E.
The vesicular
monoamine transporter 2 (VMAT2) is
expressed by normal and tumor cutaneous mast cells and Langerhans cells
of the
skin but is absent from Langerhans cell histiocytosis.
J. Histochem. Cytochem., 2004;52:779-88.
pubmed link
Möller JC, ,
Kolsch H, Lohmuller F,
Bandmann O, Gocke P, Du Y, Paus S, Wullner U, Gasser T, , Klockgether T,
Dodel RC.
Lack of
association between the interleukin-1 alpha (-889) polymorphism and
early-onset
Parkinson's disease.
Neurosci. Lett.,
2004;359:195-7.
pubmed link
,
Lohmüller F, Gocke P, Du Y, Zimmer
R, Gasser T, Klockgether T, Dodel RC.
An interleukin-6
promoter variant is not
associated with an increased risk for Alzheimer's disease.
Dement. Geriatr. Cogn. Disord., 2004;17:170-3.
pubmed link
Lannuzel A,
Michel PP, ,
Champy
P, Jousset A, Darios F, Gleye C, Laurens A, Hocquemiller R, Hirsch E,
Ruberg M.
The mitochondrial
complex I inhibitor annonacin is a new candidate toxin for
Parkinsonism.
Neuroscience, 2003;121:287-96.
Depino AM, Earl C, Kaczmarczyk E, Ferrari C, Besedovsky H, del Rey A,
Pitossi
FJ, .
Microglial
activation with atypical proinflammatory
cytokine expression in a rat model of Parkinson's disease.
Eur. J. Neurosci., 2003;18:2731-42.
,
Carrard G, Michel PP, Friguet B,
Hirsch EC.
Dysfunction of
mitochondrial complex I and the proteasome:
Interactions between two biochemical deficits in a cellular model of
Parkinson’s disease.
J.
Neurochem.,
2003;86:1297-1307.
, Féger J,
Prigent A, Michel PP,
Parain K, Champy P, Ruberg M, , Hirsch
EC. Chronic systemic
complex I inhibition induces a hypokinetic multisystem
degeneration in rats.
J. Neurochem., 2003;84:491-503.
,
Du Y, Muller U, Kurz A, Zimmer R,
Riemenschneider M, Gasser T, ,
Klockgether T, Dodel RC, Oertelf WH.
Lack
of association of interleukin-10 promoter region polymorphisms with
Alzheimer's disease.
Neurosci. Lett.,
2003;342:132-4.
Dodel RC, Du Y, ,
Kurz A, Eastwood B,
Farlow M, ,
Muller U, Riemenschneider
M.
A polymorphism in
the cystatin C promoter region is not associated with an
increased risk of AD. Neurology, 2002;58:664.
Dodel R, Hampel H, ,
Lin S, Gao F,
Schock S, Jackel S, Wei X, Buerger K, Hoft C, Hemmer B, Moller HJ,
Farlow M, ,
Sommer N, Du Y.
Human antibodies
against
amyloid beta peptide: a potential treatment for Alzheimer's disease.
Ann. Neurol., 2002;52:253-6.
Themann C, ,
Gross S,
Westermann R, Weihe E, Kuschinsky K, Schafer H, Ferger B. Effect of repeated
treatment with high doses of selegiline on behaviour, striatal
dopaminergic
transmission and tyrosine hydroxylase mRNA levels.
Naunyn
Schmiedebergs Arch. Pharmacol.,
2002;365:22-8.
,
Widmer HR, Spenger C, Meyer M,
Seiler RW, ,
Sautter J.
Culturing rat
fetal ventral mesencephalon prior to intrastriatal grafting: Influence
of
culture time and BDNF treatment on graft survival and function.
Exp. Neurology,
2001;167:148–57.
,
Schafer MK, Ferger B, Gross S,
Westermann R, Weihe E, Kuschinsky K.
Sensitization to
the behavioural effects
of cocaine: alterations in tyrosine hydroxylase or endogenous opioid
mRNAs are
not necessarily involved.
Naunyn Schmiedebergs Arch. Pharmacol.,
2001;363:288-94.
Sautter J, ,
,
Earl CD.
GM1-ganglioside
improves survival
and function of cryopreserved embryonic midbrain grafted to the
6-hydroxydopamine-lesioned rat striatum.
Exp. Neurology, 2000;164:121–9.
,
Sautter J, Meyer M, Spenger C,
Seiler RW, ,
Widmer HR.
Rat fetal ventral
mesencephalon grown as
solid tissue cultures: Influence of culture time and BDNF treatment on
dopamine
neuron survival and function.
Brain Res., 1998;813:313-22.
Weihe E, Schafer MK, Schutz B, Anlauf M, ,
Brett C, Chen L, Eiden LE.
From
the cholinergic gene locus to the cholinergic neuron.
J. Physiol. Paris., 1998;92:385-8.